The new service, iHOP-FuncNetConn, uses unweighted co-occurrences of gene and protein names to estimate the probability of a genuine connection between each pair found in the literature. This gives it broader coverage of the genome, but the scores it produces are slightly less reliable.

The original service, iHOP-FuncNet, is still available. This uses weighted connections between names found in the literature, calculated in advance over the whole human/mouse co-occurrence network. As a result, the scores are more accurate but the coverage is lower.