Information Hyperlinked over Proteins
A network of concurring genes and proteins extends through the scientific literature touching on phenotypes, pathologies and gene function.
The iHOP server provides this network as a natural way of accessing millions of PubMed abstracts. By using genes and proteins as hyperlinks between sentences and abstracts, the information in PubMed can be converted into one navigable resource, bringing all advantages of the internet to scientific literature research.
For more information on iHOP, see Hoffmann & Valencia (2004).
iHOP provides two web services which exploit these literature links to identify functionally related proteins: the ‘classic’ version which has more reliable scores but slightly lower coverage, and the iHOP-FuncNetConn service which has better coverage at the expense of score reliability.
