Gene Ontology Semantic Similarity
GOSS uses the semantic similarity measure between GO terms detailed in Lord et al (2003) to score proteins for similarity of function. Even if two proteins have no actual GO annotations directly in common, they may be annotated with terms that are very closely related, by virtue of their shared information content.
GOSS predicts functional similarity via the three branches of GO separately: biological process (GossBpService), cellular component (GossCcService) and molecular function (GossMfservice).
