GENe AnaloGue FINdEr
GENe AnaloGue FINdEr (ENGINE) uses semantic similarity between GO terms to score proteins for similarity of function. Even if two proteins have no actual GO annotations directly in common, they may be annotated with terms that are very closely related, by virtue of their proximity in the GO graph and mutual information content. ENGINE was designed to detect such implicit associations via large-scale grid-based statistical analysis, and engineDB contains the results of this analysis.
The ENGINE web server allows queries to be submitted directly, for 150,000 organisms — the engineDB FuncNet service is currently human-only as this is the baseline supported by all FuncNet predictors.
More information on ENGINE can be found in Tulipano et al. (2007).
